diff --git a/packages/discord.js/src/structures/MessagePayload.js b/packages/discord.js/src/structures/MessagePayload.js
index 7dc567924..5420d250d 100644
--- a/packages/discord.js/src/structures/MessagePayload.js
+++ b/packages/discord.js/src/structures/MessagePayload.js
@@ -149,15 +149,12 @@ class MessagePayload {
 
     let flags;
     if (
-      this.options.flags !== undefined ||
+      // eslint-disable-next-line eqeqeq
+      this.options.flags != null ||
       (this.isMessage && this.options.reply === undefined) ||
       this.isMessageManager
     ) {
-      flags =
-        // eslint-disable-next-line eqeqeq
-        this.options.flags != null
-          ? new MessageFlagsBitField(this.options.flags).bitfield
-          : this.target.flags?.bitfield;
+      flags = new MessageFlagsBitField(this.options.flags).bitfield;
     }
 
     let allowedMentions =
diff --git a/packages/discord.js/src/structures/interfaces/InteractionResponses.js b/packages/discord.js/src/structures/interfaces/InteractionResponses.js
index 1f33486ca..899ef6474 100644
--- a/packages/discord.js/src/structures/interfaces/InteractionResponses.js
+++ b/packages/discord.js/src/structures/interfaces/InteractionResponses.js
@@ -4,6 +4,7 @@ const { makeURLSearchParams } = require('@discordjs/rest');
 const { isJSONEncodable } = require('@discordjs/util');
 const { InteractionResponseType, MessageFlags, Routes, InteractionType } = require('discord-api-types/v10');
 const { DiscordjsError, ErrorCodes } = require('../../errors');
+const MessageFlagsBitField = require('../../util/MessageFlagsBitField');
 const InteractionCallbackResponse = require('../InteractionCallbackResponse');
 const InteractionCollector = require('../InteractionCollector');
 const InteractionResponse = require('../InteractionResponse');
@@ -75,11 +76,13 @@ class InteractionResponses {
   async deferReply(options = {}) {
     if (this.deferred || this.replied) throw new DiscordjsError(ErrorCodes.InteractionAlreadyReplied);
 
+    const resolvedFlags = new MessageFlagsBitField(options.flags);
+
     const response = await this.client.rest.post(Routes.interactionCallback(this.id, this.token), {
       body: {
         type: InteractionResponseType.DeferredChannelMessageWithSource,
         data: {
-          flags: options.flags,
+          flags: resolvedFlags.bitfield,
         },
       },
       auth: false,
@@ -87,7 +90,7 @@ class InteractionResponses {
     });
 
     this.deferred = true;
-    this.ephemeral = Boolean(options.flags & MessageFlags.Ephemeral);
+    this.ephemeral = resolvedFlags.has(MessageFlags.Ephemeral);
 
     return options.withResponse
       ? new InteractionCallbackResponse(this.client, response)
@@ -131,7 +134,7 @@ class InteractionResponses {
       query: makeURLSearchParams({ with_response: options.withResponse ?? false }),
     });
 
-    this.ephemeral = Boolean(options.flags & MessageFlags.Ephemeral);
+    this.ephemeral = Boolean(data.flags & MessageFlags.Ephemeral);
     this.replied = true;
 
     return options.withResponse